Press down to dispense—use only pea-sized amount of formula.Apply once a day, morning or night. Regardless of application time, make sure youuse SPFprotection in the morning.To ensure even application, apply one dot of formula onto each of the following areas: forehead, right cheek, left cheek, nose, chin, and neck,avoiding the eye and lip areas.If you have very sensitive skin or prefer to slowly introduce retinol into your routine, start with twice-weekly application, then gradually increase frequency to every other night, and finally once daily as tolerated